![]() Both linear and nonlinear effects were evaluated to explain the impact of food intake on drug absorption. The model was developed by nonlinear mixed effect modeling method. MethodsĬlinical data from a fenofibrate PK study involving three different conditions (fasting, standard meals and high-fat meals) were used. The aim of this study was to develop a mechanistic GI absorption model for explaining the effect of food on fenofibrate pharmacokinetics (PK), focusing on the food type and calorie content. ![]() ![]() Consumption of food is one of the major factors affecting the GI system and consequently the absorption of drugs. Oral administration of drugs is convenient and shows good compliance but it can be affected by many factors in the gastrointestinal (GI) system. ![]()
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