The Express Tribune dug out their past works and their road to glory. The investiture ceremony of the awards will take place on Pakistan Day, March 23, 2012.Īctors Noman Ejaz, Javed Sheikh, Meera and Saba Hameed, along with director-producer Kazim Pasha and Sahira Kazmi were awarded with the pride of performance awards for their services in film and television. President Asif Ali Zardari announced civil awards – Nishan-i-Imtiaz, Hilal-i-Pakistan, Hilal-i-Imtiaz, Sitara-i-Pakistan, Sitara-i-Shuja’at, Sitara-i-Imtiaz, Pride of Performance, Sitara-i-Quaid-i-Azam, Tamgha-i-Pakistan, Tamgha-i-Shuja’at, Tamgha-i-Imtiaz and Tamgha-i-Khidmat – for a number of people belonging to different fields, ranging from public service to arts to literature etcetera. It was Pakistan’s 64 birthday and what better way to celebrate it than to reward people for excellence in various fields.
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Hunter (2006) Interspecies allometric scaling: prediction of clearance in large animal species: Part II: mathematical considerations. Martinez (2008) Prediction of xenobiotic clearance in avian species using mammalian or avian data: How accurate is the prediction? J. Isaza (2008) Concepts and issues with interspecies scaling in zoological medicine. In Handbook of Experimental Pharmacology: Comparative and Veterinary Pharmacology, vol. Hunter (2010) Interspecies allometric scaling. Allometry is a useful tool to help with first dose in human selection, but it is of VERY VERY limited value in other species. rat, dog, human), for many drugs, this relationship is not appear to be appropriate outside of this narrow number of species. While there may be a relationship between certain species (ie. I do not wish to restart a topic that has made it's appearance on this listserv more times than I can count (I have only been a member since the early '90s), but I must restate, expecting many to weigh in, that Vd/BW is not a constant. On at 14:18:16, Robert P Hunter (HUNTER_ROBERT_P.) sent the message.byĬonsidering a direct relationship between Vd and Body Weight (BW), i.e. (Vd) can be scaled allometrically by applying the exponent 1.00, i.e. Useful starting point for interspecies volume of distribution concerns couldīe the evidence that, for many conventional drugs, Volume of Distribution The following message was posted to: PharmPK On at 17:07:37, Stefano Porzio () sent the message.Is it similar or different in different species? This question has puzzled me for a long time and it's hard to find a useful paper to help me. But I don't know very clearly about the breakpoint values for volume of distribution. On at 05:37:38, wangjian (wj801126.at.) sent the messageĭoes anyone can tell me or provide me some useful paper about how to interpret a certain value of volume of distribution when we get it from mouse, rat or dog, monkey preclinical PK studies? Just like we can differentiate the drug with plasma clearance as low, medium or high hepatic extracted drug when the values located in the range of 70%HBF, respectively.PharmPK Discussion List Archive - PK2010163.html - 2010 PharmPK Discussion - Interpret volume of distribution PharmPK Discussion List Archive Index page Once the formatting completes, an Info window will appear congratulating you for a successful install.The app will open another Warning window confirming if you want to reformat the drive.A Warning window will pop up, asking you if you want to continue.Once you're ready to format your USB drive, click on Install.This action digitally signs your boot drive so modern, more secure systems will read your boot drive as valid. 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